Endocrine Abstracts

Introduction: Hypothalamus or pituitary disorders frequently cause hypopituitarism. Diagnosing deficits of anterior pituitary hormones is important to manage metabolic impairments induced by hypopituitarism. Provocative tests including TRH, LHRH, CRH and GHRP-2 to diagnose hypopituitarism are recommended in Japan, however, the cut-off values in those tests are not adjusted for age, body mass index (BMI) or estimated glomerular filtration rate (eGFR). We retrospectively evaluat...

Background: It has been suggested that higher arginine vasopressin (AVP) concentration may be associated with greater eGFR decline in diabetic patients not using inhibitors of the renin-angiotensin system (Diabetologia 2013). If excessive AVP action is detrimental to renal prognosis, then diabetic patients with central diabetes insipidus (CDI) may have relatively preserved renal function. Therefore, we aimed to compare long-term renal prognosis of diabetic patients with and wi...

Background: Growth hormone (GH) deficiency, which causes visceral obesity and non-alcohol fatty liver disease, increases cardiovascular event risks. High-sensitivity C-reactive protein (hs-CRP), an inflammatory marker associated with increased cardiovascular risk, reportedly decreased after GH supplementation in GH-deficient patients, however, the association between GH secretion and inflammation remains unclear.Patients and Methods: We retrospectively i...

Background: (Pro)renin receptor[(P)RR] is a multi-functioning transmembrane protein which plays key roles in the regulation of tissue renin-angiotensin system (RAS). (P)RR is cleaved by furin to generate soluble (P)RR[s(P)RR], which is secreted into extracellular space. We previously reported that high blood concentration of s(P)RR indicates poor organ prognosis in several diseases. In this way, s(P)RR is expected as a candidate biomarker for reflecting the tissue RAS status, ...

Introduction: Sarcoidosis is a systemic granulomatous disorder usually affects multiple organs. Approximately 10% of sarcoidosis occurs as isolated neurosarcoidosis in CNS and <10% of neurosarcoidosis develops in a restricted hypothalamic–pituitary area. Recent study has identified Propionibacterium acnes in lungs and lymph nodes of many patients with sarcoidosis using a MAB specific for this bacterium (PAB), providing strong evidence for P. acne as ...

Background: Growth hormone (GH) deficiency causes visceral obesity and fatty liver and increases cardiovascular event risks. Because serum high-sensitivity C-reactive protein (hs-CRP) levels, which has been used to estimate those risks, was reported to be decreased by GH supplementation therapy in GH deficient patients, it has been suggested that inflammatory processes might be activated in GH deficient state. However, the clinical factors associated with increased hs-CRP leve...

Backgrounds: Podocytes are highly specialized postmitotic kidney cells that contribute to maintaining the filtration barrier and normal structure of glomerular capillaries. The (pro)renin receptor (PRR), as ATP6AP2, is an accessory subunit of the vacuolar H+-ATPase (V-ATPase), implying more fundamental, developmental functions for the PRR in addition to its role in activating the local renin-angiotensin system.Results: Podocyte-specific conditional (P)RR...

Introduction: TSH-secreting pituitary adenoma (TSHoma) sometimes brings on rare cause of hyperthyroidism because of its excessive TSH secretion. Though the first line of treatment for TSHoma is surgical removal of tumour, hyperthyroidism often causes perioperative thyroid storm. Here, we report a case of GH-TSH pituitary adenoma whose thyrotoxicosis was controlled by 5 days’ octoreotide (OCT) subcutaneous administration before surgery.Case report: A...